Marchiafava-Bignami Disease

Unknown Brain Case 12


75 y/o man presenting with difficulty naming objects held in his right hand.

Image Findings

Focal areas of demyelination and necrosis are noted in the corpus callosum and adjacent white matter. Abnormal diffuse increased intensity is seen throughout the corpus callosum on the FLAIR sequence.


This patient had a history of consuming large amounts of home made wine. He was unable to name objects placed in his right hand but was able to name them when placed in his left hand, indicating an abnormality in the corpus callosum. This is an uncommon disease associated with alcoholism.

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Last modified February 7, 1997
Copyright 1997 Ray Ballinger, University of Florida and VA Medical Center, Gainesville, FL.